2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-171531
    2'-O-MOE-UTP
    2'-O-MOE-UTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-O-MOE-UTP
  • HY-154362A
    β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-4-methylbenzoate
    β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate) (compound 25) displays potent tumor cell growth inhibition activity.
    β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-4-methylbenzoate
  • HY-160704
    CMX-521
    CMX-521, a nucleoside analog, is a potent inhibitor for RNA-dependant RNA polymerase (RdRp) of norovirus. CMX-521 suppresses murine norovirus (MNV) and human norovirus.
    CMX-521
  • HY-178545
    DMTr-2'-O-C6-rU-3'-CE-phosphoramidite
    DMTr-2'-O-C6-rU-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-C6-rU-3'-CE-phosphoramidite
  • HY-185257
    Tryptamino-dUTP
    Tryptamino-dUTP is a nucleotide triphosphate analog modified at the 5-position (R) of uridine (dUTP).
    Tryptamino-dUTP
  • HY-178609
    TPT3TP
    TPT3TP is a monomeric raw material that can be used for nucleic acid synthesis.
    TPT3TP
  • HY-101969R
    Pseudothymidine (Standard)
    		Chemical
    Pseudothymidine (Standard) is the analytical standard of Pseudothymidine (HY-101969). This product is intended for research and analytical applications. Pseudothymidine is a C-nucleoside analog of thymidine.
    Pseudothymidine (Standard)
  • HY-178684
    DMTr-dI-3'-(D)-PSM-phosphoramidite
    DMTr-dI-3'-(D)-PSM-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-dI-3'-(D)-PSM-phosphoramidite
  • HY-156843
    Antiproliferative agent-38
    Antiproliferative agent-38 (com 18) is a tetracyclic ring, but its most reactive ring nitrogen (probably the quinoline moiety) cannot undergo N-alkylation. Antiproliferative agent-38 lacks anti-malarial activity and lacks anti-cancer cell proliferation activity.
    Antiproliferative agent-38
  • HY-178592
    5'-OH-(2'OMe-G)pG
    5'-OH-(2'OMe-G)pG is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-OH-(2'OMe-G)pG
  • HY-W1121759
    DMTr-2'-ara-F-dG(dmf)-3'-CE-phosphoramidite
    DMTr-2'-ara-F-dG(dmf)-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-ara-F-dG(dmf)-3'-CE-phosphoramidite
  • HY-137667
    2'-Deoxy-3',5'-CDP
    2'-Deoxy-3',5'-CDP (pdCp) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-Deoxy-3',5'-CDP
  • HY-W784571
    2'-OMe-uTP
    2'-OMe-uTP is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-OMe-uTP
  • HY-137701
    ddATPαS
    ddATPαS is a dideoxynucleotide that can be used for DNA sequencing.
    ddATPαS
  • HY-W013159R
    2'-Deoxyguanosine 5'-monophosphate disodium (Standard)
    2'-Deoxyguanosine 5'-monophosphate (disodium) (Standard) is the analytical standard of 2'-Deoxyguanosine 5'-monophosphate (disodium) (HY-W013159). This product is intended for research and analytical applications. 2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis.
    2'-Deoxyguanosine 5'-monophosphate disodium (Standard)
  • HY-102071R
    KIN59 (Standard)
    		Inhibitor
    KIN59 (Standard) is the analytical standard of KIN59 (HY-102071). This product is intended for research and analytical applications. KIN59 (5’-O-Tritylinosine) is a potent thymidine phosphorylase allosteric inhibitor. KIN59 inhibits FGF2-stimulated cell growth. KIN59 inhibits the expression of p-FGFR1, P-Akt in FGF2 (10 ng/mL) stimulated cells. KIN59 shows anti-tumor activity.
    KIN59 (Standard)
  • HY-W670604
    3'-O-Phthalimido-2'-deoxythymidine
    3'-O-Phthalimido-2'-deoxythymidine (3'-O-phthalimido-2'-dT) is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-Phthalimido-2'-deoxythymidine
  • HY-U00130
    1-Acetyl-3-o-toluyl-5-fluorouracil
    1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antitumor agent and a 5-fluorouracil analog.
    1-Acetyl-3-o-toluyl-5-fluorouracil